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RF9 is a selective NPFF receptor antagonist (Ki values are 58 and 75 nM at hNPFF1 and hNPFF2 receptors respectively). RF9 displays selectivity over several related receptors including NPY Y1 GPR10, GPR54, GPR103 and the opioid receptors. RF9 blocks NPFF-induced hypothermia and increases in atrial blood pressure and heart rate, and prevents opioid-induced tolerance associated with hyperalgesia in vivo. RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance. RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate.
| Molecular Weight | 482.62 |
| Formula | C26H38N6O3 |
| CAS Number | 876310-60-0 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL Water ≥ 10 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Neuropeptide Receptor Products |
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| JNJ-31020028
JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors. |
| BIBO 3304 trifluoroacetate
BIBO 3304 trifluoroacetate is a highly selective NPY Y 1 receptor antagonist. |
| CYM 9484
CYM 9484 is a potent NPY Y 2 receptor antagonist. |
| L-152,804
L-152,804 is a potent, selective non-peptide NPY Y 5 receptor antagonist. |
| NTNCB hydrochloride
NTNCB hydrochloride is a potent and selective non-peptidic NPY Y 5 antagonist. |
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Products are for research use only. Not for human use. We do not sell to patients.
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