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NTNCB hydrochloride is a selective, non-peptide competitive NPY Y5 antagonist. Ki values are 8.0 and 16032 nM at human recombinant Y5 and Y1 receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Displays some affinity for cloned human D2 and α2C receptors (Ki values are 63 and 100 nM respectively).
| Molecular Weight | 508.07 |
| Formula | C25H33N3O4S.HCl |
| CAS Number | 191931-56-3 |
| Solubility (25°C) | DMSO 50.81 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Neuropeptide Receptor Products |
|---|
| JNJ-31020028
JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors. |
| BIBO 3304 trifluoroacetate
BIBO 3304 trifluoroacetate is a highly selective NPY Y 1 receptor antagonist. |
| CYM 9484
CYM 9484 is a potent NPY Y 2 receptor antagonist. |
| L-152,804
L-152,804 is a potent, selective non-peptide NPY Y 5 receptor antagonist. |
| RF9
RF9 is a selective NPFF receptor antagonist (Ki values are 58 and 75 nM at hNPFF1 and hNPFF2 receptors respectively). |
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