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QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18.
| Molecular Weight | 1990.13 |
| Formula | C92H148O46 |
| CAS Number | 141256-04-4 |
| Solubility (25°C) | DMSO 80 mg/mL Water 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Adjuvants Products |
|---|
| Lentinan
Lentinan is purified β-glucan from Shiitake mushrooms, also used as adjuvant. |
| Aluminum stearate
Aluminum stearate is a saline form of stearic acid used as a thickener and emulsifier, and to regulate the stability and suspension of a cosmetic formulation, used as adjuvant. |
| Lanolin
Lanolin is a complex waxy substance composed of varying quantities of long-chain waxy esters and lanolin alcohols, acids and polycarbons, used as adjuvant. |
| 5'-Cytidylic acid
Cytidine 5′-monophosphate (5'-CMP) is used as a substrate of uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) to form CDP which upon phosphorylation to CTP supports DNA and RNA biosynthesis; used as adjuvant. |
| KIN1148
KIN1148 is a IRF3 agonist, it is also a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy. |
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