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KIN1148 is a IRF3 agonist, it is also a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy. KIN1148 induced dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. Prime-boost immunization of mice with a suboptimal dose of a monovalent pandemic influenza split virus H1N1 A/California/07/2009 vaccine plus KIN1148 protected against a lethal challenge with mouse-adapted influenza virus (A/California/04/2009) and induced an influenza virus-specific IL-10 and Th2 response by T cells derived from lung and lung-draining lymph nodes.
| Molecular Weight | 361.44 |
| Formula | C19H11N3OS2 |
| CAS Number | 1428729-56-9 |
| Solubility (25°C) | DMSO: ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Adjuvants Products |
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| Lentinan
Lentinan is purified β-glucan from Shiitake mushrooms, also used as adjuvant. |
| Aluminum stearate
Aluminum stearate is a saline form of stearic acid used as a thickener and emulsifier, and to regulate the stability and suspension of a cosmetic formulation, used as adjuvant. |
| Lanolin
Lanolin is a complex waxy substance composed of varying quantities of long-chain waxy esters and lanolin alcohols, acids and polycarbons, used as adjuvant. |
| 5'-Cytidylic acid
Cytidine 5′-monophosphate (5'-CMP) is used as a substrate of uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) to form CDP which upon phosphorylation to CTP supports DNA and RNA biosynthesis; used as adjuvant. |
| Astragalus Polysacharin
Astragalus Polysacharin is a natural product from Astragalus membranaeus, used as adjuvant, attenuates TNF-α-induced insulin resistance by suppressing miR-721 and activating PPAR-γ and PI3K/Akt in 3T3-L1 adipocytes. |
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