All AbMole products are for research use only, cannot be used for human consumption.
GW4869 (GW69A, GW554869A) is a noncompetitive inhibitor of neutral Smase (spspingolipase) with IC50 of 1 μM. GW4869 is selective for N-smase and has no inhibitory effect on acidic SMase at concentrations up to 150 μm. GW4869 is also an inhibitor of exosome synthesis/release. LPS-triggered exosome generation was remarkably attenuated in macrophages upon pre-treatment of macrophages with 10 μM GW4869, as evidenced by a 22% reduction in the activity of AChE. Such attenuation was further enhanced by treatment with 20 μM GW4869. GW4869 prevented CLP-induced diaphragm calpain activation and diaphragm weakness in mice.
*GW4869 is usually formulated as a suspension.
Sci Rep. 2025 Sep 01;15(1):32226.
Umbilical cord-derived exosomes alleviate spinal cord injury by regulating microglial polarization through miR-340-5p-mediated modulation of the JAK/STAT3 signaling pathway
GW4869 2HCl purchased from AbMole
Int J Biol Sci. 2023 Sep 4;19(15):4744-4762.
Hypoxia-induced exosomes facilitate lung pre-metastatic niche formation in hepatocellular carcinoma through the miR-4508-RFX1-IL17A-p38 MAPK-NF-κB pathway
GW4869 2HCl purchased from AbMole
Int Immunopharmacol. 2023 Nov 27;126:111301.
Inhibition of circulating exosomes release with GW4869 mitigates severe acute pancreatitis-stimulated intestinal barrier damage through suppressing NLRP3 inflammasome-mediated pyroptosis
GW4869 2HCl purchased from AbMole
Cell Death Dis. 2021 Aug 27;12(9):815.
Extracellular vesicles package dsDNA to aggravate Crohn’s disease by activating the STING pathway
GW4869 2HCl purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | hucMSCs |
| Preparation method | Both the miR-340-5p mimic and the miR-340-5p inhibitor underwent transfection into hucMSCs, followed by a 48-hour cultivation at 37 °C in a 5% CO2 incubator, subsequent to which the efficiency of the transfection was assessed. Additionally, to inhibit the release of exosomes by hucMSCs, 10 µM of the exosome secretion inhibitor GW4869 (Abmole, China) was introduced into the hucMSCs medium. |
| Concentrations | 10 μM |
| Incubation time | - |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6 and STING knockout (Tmem173−/−) mice |
| Formulation | - |
| Dosages | 2.5 mg/kg |
| Administration | Intraperitoneally |
| Molecular Weight | 577.50 |
| Formula | C30H30Cl2N6O2 |
| CAS Number | 6823-69-4 |
| Solubility (25°C) | DMSO 1 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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