All AbMole products are for research use only, cannot be used for human consumption.
Difluprednate (difluoroprednisolone butyrate acetate, or DFBA) is a synthetic difluorinated prednisolone derivative, it originally developed for dermatologic applications.
 |
Source | Eye Contact Lens (2017). Figure 3. Difluprednate |
| Method | Intraocular Pressure | |
| Cell Lines | ||
| Concentrations | 16 μm | |
| Incubation Time | 24 h | |
| Results | Thirty percent (9 of 30 eyes) in the difluprednate group and 26.7% (8 of 30 eyes) in the loteprednol group developed clinically significant IOP elevation at the 1-day visit. |
 |
Source | Eye Contact Lens (2017). Figure 2. Difluprednate |
| Method | Uncorrected Visual Acuity | |
| Cell Lines | ||
| Concentrations | 16 μm | |
| Incubation Time | 24 h | |
| Results | The mean UCVA in the difluprednate group improved from 0.90 logMAR (20/159) preoperatively to 0.24 logMAR (20/34). |
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Dutch male pigmented rabbits |
| Formulation | castor oil |
| Dosages | 0.025 mg/50 mL |
| Administration | instillation |
| Molecular Weight | 508.55 |
| Formula | C27H34F2O7 |
| CAS Number | 23674-86-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 82 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Symes RJ, et al. Can J Ophthalmol. Topical difluprednate monotherapy for uveitic macular edema.
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