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Cu(II)-Elesclomol is a Cu2+ complex of Elesclomol. Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. Cu(II)-Elesclomol also weakly inhibits DNA topoisomerase I.
| Molecular Weight | 462.05 |
| Formula | C19H18CuN4O2S2 |
| CAS Number | 1224195-72-5 |
| Solubility (25°C) | DMSO 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cuproptosis Products |
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| Elesclomol
Elesclomol (STA-4783) is a novel oxidative stress inducer that acts on tumor cells and promotes their apoptosis, and is a strong copper ion-carrier that can be used for cuproptosis studies. |
| NSC 319726
NSC 319726 is a p53(R175) mutant activator that inhibits the growth of p53(R175) mutant cells and acts on p53(R175) mutant cells with IC50 of 8 nM, which has no inhibition on p53 wild-type cells. NSC 319726 is a potent copper ion-carrier that can be used in cuproptosis studies. |
| Zinc Pyrithione
Zinc Pyrithione is an anti-fungal and anti-bacterial drug that disrupts membrane transport by blocking proton pumps and is a potent copper ion carrier that can be used in copper death (cuproptosis) studies. |
| Penicillamine
Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. |
| Trientine-2HCl
Trientine-2HCl is a chelating agent used in the study of Wilson's disease by binding and scavenging copper from the body.Trientine-2HCl is also used as a chelating agent for copper in hepatocyte degeneration, as a stabilizer for epoxy resins, and as an ampholyte for isoelectric focusing. |
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