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Elesclomol (STA-4783) is a novel oxidative stress inducer that acts on tumor cells and promotes their apoptosis, and is a strong copper ion-carrier that can be used for cuproptosis studies. By Affymetrix microarray analysis, Elesclomol significantly induced the expression of heat shock stress response genes and metallothionein genes in Hs294T cells treated at 100 nM for 6 h. Ramos Burkitt's lymphoma B cells were treated with Elesclomol (100 nM) for 1 h and 6 h, respectively, and the Hsp70 RNA level was rapidly increased by 4.8 times and 160 times, which was consistent with the intracellular ROS content. After 0.5 h and 6 h Elesclomol treatment, ROS content increased by 20% and 385%, respectively. Antioxidant N-acetylcysteine (NAC) and Tiron pretreatment could inhibit the induction of Hsp70. HSB2 cells treated with 200 nM Elesclomol for 18 h could induce oxidative stress and increase the apoptotic cells in early stage and late stage by 3.7 times and 11 times, respectively. The above effects could be completely inhibited by NAC, but had no effect on normal cells.
| Molecular Weight | 400.52 |
| Formula | C19H20N4O2S2 |
| CAS Number | 488832-69-5 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cuproptosis Products |
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| NSC 319726
NSC 319726 is a p53(R175) mutant activator that inhibits the growth of p53(R175) mutant cells and acts on p53(R175) mutant cells with IC50 of 8 nM, which has no inhibition on p53 wild-type cells. NSC 319726 is a potent copper ion-carrier that can be used in cuproptosis studies. |
| Zinc Pyrithione
Zinc Pyrithione is an anti-fungal and anti-bacterial drug that disrupts membrane transport by blocking proton pumps and is a potent copper ion carrier that can be used in copper death (cuproptosis) studies. |
| Penicillamine
Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. |
| Trientine-2HCl
Trientine-2HCl is a chelating agent used in the study of Wilson's disease by binding and scavenging copper from the body.Trientine-2HCl is also used as a chelating agent for copper in hepatocyte degeneration, as a stabilizer for epoxy resins, and as an ampholyte for isoelectric focusing. |
| 2,2'-Bipyridine
2,2'-Bipyridine has been used in the preparation of copper(II)-bipyridine-naringenin complexes. It can be used for the preparation of 2,2'-bipyridine hydrobromide. 2,2'-Bipyridine has good redox stability and glucose elevating activity. |
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