All AbMole products are for research use only, cannot be used for human consumption.
Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3. Colivelin suppresses neuronal death by activating STAT3 in vitro. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease.
JPI. 2024 Jan-Feb;67(1):p 47-56.
Fatty Acid Binding Protein-4 Silencing Inhibits Ferroptosis to Alleviate Lipopolysaccharide-induced Injury of Renal Tubular Epithelial Cells by Blocking Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling
Colivelin purchased from AbMole
Recent Advances in Ophthalmology. 2023;43(3):190-194.
Effect of glia maturation factor-β on the activation of retinal Müller cells in diabetic rats and its mechanism
Colivelin purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | A2780 and OVCAR3 cells |
| Preparation method | A2780 and OVCAR3 cells were treated with different concentrations of indirubin (2 and 5 µM) or pretreated with 0.5 µM colivelin. Forty-eight hours later, the cells were washed by PBS and harvested by RIPA buffer with 1 mM phenylmethylsulfonyl fluoride on ice for 30 minutes. |
| Concentrations | 0.5 µM |
| Incubation time | 28 h |
| Animal Experiment | |
|---|---|
| Animal models | Male C57BL/6 mice |
| Formulation | 20% ethyl alcohol |
| Dosages | 1 mg/kg |
| Administration | i.p. |
| Molecular Weight | 2645.13 |
| Formula | C119H206N32O35 |
| CAS Number | 867021-83-8 |
| Solubility (25°C) | DMSO 50 mg/mL Water ≥ 1 mg/mL |
| Storage | -20°C, dry, sealed |
| Related STAT Products |
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NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM. NSC 74859 (S3I-201) is effective in hepatocellular cancers with disrupted TGF-beta signaling.*The compound is unstable in solutions, freshly prepared is recommended |
| Fludarabine
Fludarabine (NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. |
| Niclosamide
Niclosamide is an inhibitor of STAT3 with an IC50 value of 0.25 μM. |
| Nifuroxazide
Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells. |
| Stattic
Stattic is the first nonpeptidic STAT3 inhibitor, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1. Stattic inhibits STAT3 phosphorylation (at Y705 and S727). |
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Products are for research use only. Not for human use. We do not sell to patients.
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