All AbMole products are for research use only, cannot be used for human consumption.
Stattic is the first nonpeptidic STAT3 inhibitor, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1. Stattic inhibits STAT3 phosphorylation (at Y705 and S727).
J Genet Genomics. 2025 Apr 17.
Loss of lims1 causes aberrant cardiac remodeling and heart failure via activating gp130/Jak1/Stat3 pathway in zebrafish
Stattic purchased from AbMole
Chinese Journal of Analytical Chemistry. 2025 Sep 10; .
Integration of network pharmacology and experimental verification to reveal the active constituents and molecular mechanism of Compound Fujin Shengji (FJSJ) Powder in the treatment of diabetes ulcer
Stattic purchased from AbMole
Cell Mol Immunol. 2023 Jun 12.
A subpopulation of CD146+ macrophages enhances antitumor immunity by activating the NLRP3 inflammasome
Stattic purchased from AbMole
Adv Sci (Weinh). 2022 Mar 8;e2103719.
CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity
Stattic purchased from AbMole
Front Immunol. 2022 May 23;13:866638.
A Novel STAT3 Gain-of-Function Mutation in Fatal Infancy-Onset Interstitial Lung Disease
Stattic purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Ly3 cells |
| Preparation method | MTS |
| Concentrations | ~2.5 μM |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | Ly3 parental NOD/SCID IL2R null xenograft |
| Formulation | |
| Dosages | 3.75 mg/kg every day |
| Administration | i.p. |
| Molecular Weight | 211.19 |
| Formula | C8H5NO4S |
| CAS Number | 19983-44-9 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Sijia Li, et al. Stattic alleviates acute hepatic damage induced by LPS/d-galactosamine in mice
[5] Jochen Schust, et al. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization
| Related STAT Products |
|---|
| Artesunate
Artesunate is a potential STAT3 inhibitor that acts on the small cell lung cancer cell line H69 with an IC50 value of < 5 μM and is also used in antimalarial studies. Artesunate also promotes ROS signaling and lipid peroxidation by increasing the formation of variable iron pools, ultimately leading to iron death in pancreatic cancer cells. |
| NSC 74859 (S3I-201)
NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM. NSC 74859 (S3I-201) is effective in hepatocellular cancers with disrupted TGF-beta signaling.*The compound is unstable in solutions, freshly prepared is recommended |
| Fludarabine
Fludarabine (NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. |
| Niclosamide
Niclosamide is an inhibitor of STAT3 with an IC50 value of 0.25 μM. |
| Nifuroxazide
Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
