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BIBP3226 TFA is a novel, selective non-peptide neuropeptide Y Y1 receptor antagonist, with Ki values of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. NPY Y(1) antagonist BIBP3226 is able to displace with low affinity, 50 -- 100 nM, the specific binding on NPFF receptors expressed in CHO cells as well as in rat dorsal spinal cord, an affinity however superior to those determined against Y(2), Y(4) or Y(5) receptors. BIBP3226 (0.5 and 5 micrograms, i.c.v.) induced an anxiogenic-like effect at the higher dose tested.
| Molecular Weight | 587.59 |
| Formula | C29H32F3N5O5 |
| CAS Number | 1068148-47-9 |
| Solubility (25°C) | DMSO 120 mg/mL Water >1 mg/mL |
| Storage | Store at ≤-20°C, protect from light, dry, sealed |
[2] P Zhang, et al. BIBP 3226 inhibition of nicotinic receptor mediated chromaffin cell secretion
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