| Cat.No. | Name | Information |
|---|---|---|
| M14566 | (2-Chloropyridin-4-yl)methanamine hydrochloride | (2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM. |
| M5783 | Methylene Blue | Methylene Blue is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase. |
| M56821 | Clorgyline | Clorgyline (M&B 9302) is an orally active, blood-brain barrier permeable and selective monoamine oxidase A (MAO-A) inhibitor. |
| M49484 | PF9601N | PF9601N is a monoamine oxidase B (MAO-B) inhibitor with neuroprotective properties in various ex vivo and in vivo models of Parkinson's disease (PD) for the study of excitotoxicity-mediated neurodegenerative diseases. In addition, PF9601N is a click chemistry reagent containing an Alkyne moiety that undergoes a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an Azide moiety. |
| M30381 | Bifemelane hydrochloride | Bifemelane hydrochloride (MCI-2016) is a potent, selective and competitive inhibitor of monoamine oxidase A (MAO-A), with a Ki of 4.20 μM. Bifemelane hydrochloride also inhibits MAO-B noncompetitively with a Ki of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease. |
| M30162 | Harmol | Harmol is an orally active monoamine oxidase (MAO) inhibitor that has anti-tumor, anti-depressant, and anti-aging effects. Harmol is a TFEB activator. Harmol can induce cell mitosis, autophagy and apoptosis. Harmol promotes the degradation of α-synuclein through the regulation of the autophagy-lysosomal pathway, improving motor deficits in mouse models of Parkinson's disease. |
| M29602 | LOX-IN-3 dihydrochloride | LOX-IN-3 dihydrochloride is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 dihydrochloride can be used for fibrosis, cancer and angiogenesis research. |
| M29601 | LOX-IN-3 | LOX-IN-3 is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 can be used for fibrosis, cancer and angiogenesis research. |
| M29270 | PXS-5153A | PXS-5153A is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. PXS-5153A could reduce crosslinks and ameliorates fibrosis. |
| M29269 | PXS-5120A | PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. PXS-5120A is >300-fold selective for LOXL2 (Ki of 83 nM; pIC50 of 8.4) over LOXL (pIC50 of 5.8). |
| M24611 | Simtuzumab | Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab can be used for the research of primary sclerosing cholangitis (PSC). |
| M20475 | Safinamide | Safinamide is an orally active, selective, reversible |
| M19461 | Eckol | Eckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC50s of 7.20 and 83.44 μM, respectively. Eckol shows antiallergic and antiviral effects. |
| M19368 | Osthenol | Osthenol (Ostenol) is a selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B. |
| M17950 | 1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione；Obtusin | 1,7-Dihydroxy-2,3,8-trimethoxy-6-methylanthracene-9,10-dione；Obtusin |
| M14568 | Rasagiline | Rasagiline (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively. |
| M14567 | Pargyline | Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. Pargyline has antihypertensive and anticancer activities. |
| M14563 | 4-Hydroxyderricin | 4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is a potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC50 of 3.43 μM. |
| M10572 | Paeonol | Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively. |
| M9663 | PXS-4728A | PXS-4728A is a selective and orally active semicarbazide-sensitive amine oxidase (SSAO) inhibitor. |
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