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Zatebradine hydrochloride

Cat. No. M5079

All AbMole products are for research use only, cannot be used for human consumption.

Zatebradine hydrochloride Structure
Synonym:

UL-FS-49

Size Price Availability
10mM*1mL in DMSO USD 108  USD108 Out of stock
10mg USD 150  USD150 Out of stock
50mg USD 640  USD640 Out of stock
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Quality Control & Documentation
Biological Activity

Zatebradine(UL-FS49) is a highly effective HCN ion channel antagonist, which can reversively reduce heart rate and inhibit hHCN1 up to 92% at 10uM concentration.

Chemical Information
Molecular Weight 493.04
Formula C26H37ClN2O5
CAS Number 91940-87-3
Form Solid
Solubility (25°C) 100 mM in water
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Matt L,et.al. Cell Mol Life Sci. HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path.

[2] Van Bogaert PP,et.al. Eur J Pharmacol. Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine.

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Zatebradine

Zatebradine(UL-FS49) is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner; 92% inhibition of the hHCN1-mediated current at 10 uM.

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Keywords: Zatebradine hydrochloride, UL-FS-49 supplier, HCN Channel, inhibitors, activators

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