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VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor.
| Cell Experiment | |
|---|---|
| Cell lines | EPCs |
| Preparation method | The viability of EPCs was determined with a cell counting kit-8. EPCs were seeded in 96-well plates at a density of 3 × 10^3 cells/well and treated with different concentrations of MPS (0, 10, 20, 50 μM) for 48 h or treated with 50-μM MPS added with different concentrations of VO-OHpic (0, 0.01, 0.1, 1, 10 μM) for 48 h. |
| Concentrations | 0, 0.01, 0.1, 1, 10 μM |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | Sprague-Dawley rats |
| Formulation | DMSO |
| Dosages | 10 mg/kg |
| Administration | Intraperitoneal injection |
| Molecular Weight | 415.2 |
| Formula | C12H9N2O8V · H · 3H2O |
| CAS Number | 476310-60-8 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PTEN Products |
|---|
| SF1670
SF1670 is a pTPN2 and PTEN inhibitor. |
| bpV(HOpic) potassium salt
BpV(HOpic) is a protein tyrosine phosphatases (PTPs) and a potent PTEN inhibitor with IC50 of 14 nM. |
| Ginkgolic acid 17:1
Ginkgolic acid 17:1, a natural product isolated from Ginkgo biloba, inhibits constitutive and inducible STAT3 activation by inducing PTEN and SHP-1 tyrosine phosphatases. In addition, Ginkgolic acid C17:1 has anticancer activity. |
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