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SF1670 is a pTPN2 and PTEN inhibitor (IC50values are 0.95 and 1.78 μM, respectively). SF1670 increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. SF1670 also inhibits CD45.
| Cell Experiment | |
|---|---|
| Cell lines | A2780 and SKOV3 cells |
| Preparation method | The cells transfected with constitutively active forms of Akt (caAkt) or pretreated PTEN inhibitor (SF1670) were exposed to 100 µM resveratrol for 48 h, and cell viability was determined by MTT assay. |
| Concentrations | 100 μM |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | Swiss albino male mice |
| Formulation | DMSO |
| Dosages | 3 mg/kg |
| Administration | i.p. |
| Molecular Weight | 307.34 |
| Formula | C19H17NO3 |
| CAS Number | 345630-40-2 |
| Solubility (25°C) | DMSO 30.73 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PTEN Products |
|---|
| VO-OHpic trihydrate
VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor. |
| bpV(HOpic) potassium salt
BpV(HOpic) is a protein tyrosine phosphatases (PTPs) and a potent PTEN inhibitor with IC50 of 14 nM. |
| Ginkgolic acid 17:1
Ginkgolic acid 17:1, a natural product isolated from Ginkgo biloba, inhibits constitutive and inducible STAT3 activation by inducing PTEN and SHP-1 tyrosine phosphatases. In addition, Ginkgolic acid C17:1 has anticancer activity. |
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