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Tetrabenazine (Ro 1-9569) is a compound for the symptomatic treatment of hyperkinetic movement disorder. Tetrabenazine works mainly as a VMAT-inhibitor and as such promotes the early metabolic degradation of monoamines, in particular the neurotransmitter dopamine.
| Molecular Weight | 317.42 |
| Formula | C19H27NO3 |
| CAS Number | 58-46-8 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Michael A Cummings, et al. Deuterium Tetrabenazine for Tardive Dyskinesia
[3] No authors listed. J Pharm Belg. Tetrabenazine (tetrabenazine Orphan) orally
| Related Monoamine Transporter Products |
|---|
| Valbenazine
Valbenazine (NBI-98854) is a vesicular monoamine transporter-2 (VMAT2) inhibitor with a Ki of 110-190 nM. |
| 13-Hydroxyisobakuchiol
Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol) is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM). |
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