All AbMole products are for research use only, cannot be used for human consumption.
Treatment with the kinin B1 receptor antagonist, SSR240612, provided a protective effect against organ damage by interfering with multiple target functions, including the suppression of B1R-induced inflammation and platelet aggregation.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
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| Animal models | C57BL/6J mice |
| Formulation | |
| Dosages | 10 mg/kg |
| Administration | gavage |
| Molecular Weight | 793.41 |
| Formula | C42H53ClN4O7S |
| CAS Number | 464930-42-5 |
| Form | Solid |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Bradykinin Receptor Products |
|---|
| ELN 441958
ELN-441958 is a potent, neutral, competitive and selective oral bioavailable bradykinin B1 receptor antagonist with a Ki of 0.26 nM against native human bradykinin B1 receptor. |
| Icatibant (HOE 140) acetate
Icatibant (HOE-140) acetate is a potent and specific peptide antagonist of bradykinin B2 receptor, with IC50 value of 1.07 nM and Ki value of 0.798 nM, respectively. |
| Bradykinin
Bradykinin (bradykinin) is a vasodilator active peptide produced by the kinin-releasing enzyme-kinin system that modulates inflammation by causing vasodilation, increasing vascular permeability, and stimulating prostaglandin synthesis. |
| Icatibant
Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively. |
| [Des-Arg9]-Bradykinin
[Des-Arg9]-Bradykinin is a Bradykinin (B1) receptor agonist that displays selectivity for B1 over B2 receptors. |
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