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Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.
| Molecular Weight | 1304.52 |
| CAS Number | 130308-48-4 |
| Form | Solid |
| Solubility (25°C) | Water 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Sabrina W Cole, et al. Icatibant for the treatment of hereditary angioedema
[3] Eline A Dubois, et al. Icatibant
| Related Bradykinin Receptor Products |
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Treatment with the kinin B1 receptor antagonist, SSR240612, provided a protective effect against organ damage by interfering with multiple target functions, including the suppression of B1R-induced inflammation and platelet aggregation. |
| Icatibant (HOE 140) acetate
Icatibant (HOE-140) acetate is a potent and specific peptide antagonist of bradykinin B2 receptor, with IC50 value of 1.07 nM and Ki value of 0.798 nM, respectively. |
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