All AbMole products are for research use only, cannot be used for human consumption.
SR9238 induces increased interaction of CoRNR box peptides derived from NCoR (NCoR ID1 and NCoR ID2) with both LXRα and LXRβ, while causing decreased interaction with a coactivator NR box peptide derived from TRAP220. SR9238-induced recruitment of CoRNR box peptides is dose-dependent for both LXRα and LXRβ. HepG2 cells treated with SR9238 result in a significant decrease in Fasn and Srebp1c mRNA expression.
SR9238-treated mice display greatly reduced lipid content in the liver. SR9238-treated DIO mice display considerably lower intensity of F4/80 staining versus vehicle-treated DIO mice consistent with a beneficial effect of SR9238 on non-alcoholic steatohepatitis.
Environ Sci Technol. 2024 May 14;58(19):8182-8193.
Association of Di(2-ethylhexyl) Terephthalate and Its Metabolites with Nonalcoholic Fatty Liver Disease: An Epidemiology and Toxicology Study
SR9238 purchased from AbMole
| Molecular Weight | 595.73 |
| Formula | C31H33NO7S2 |
| CAS Number | 1416153-62-2 |
| Solubility (25°C) | DMSO ≥ 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Liver X Receptor Products |
|---|
| GW3965 hydrochloride
GW3965 hydrochloride is a selective, orally active non-steroidal synthetic liver X receptor (LXR) agonist. |
| T0901317
T0901317 is a potent and selective agonist for both LXRα and LXRβ with an EC50 of 20~50 nM. T0901317 activates FXR with an EC50 of 5 μM. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively. |
| SR9243
SR9243 is a potent and selective LXR inverse agonist. |
| LXR-623
LXR-623 is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier. |
| GSK2033
GSK2033 is a potent LXR antagonist. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
