All AbMole products are for research use only, cannot be used for human consumption.
SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo.
| Molecular Weight | 490.06 |
| CAS Number | 912545-86-9 |
| Solubility (25°C) | DMSO ≥ 38 mg/mL |
| Storage | 2-8°C, protect from light |
[2] Erdal Sag. ECI Biocommentary: Erdal Sag
[5] Joshua A Metzl. Naviculocuneiform Sag in the Acquired Flatfoot: What to Do
| Related Smo Products |
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| GDC-0449 (Vismodegib)
GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively. |
| Purmorphamine
Purmorphamine is a small molecule Hh agonist which activates the hedgehog pathway by directly binding to SMO. |
| BMS-833923
BMS-833923 is an orally bioavailable Smoothened antagonist. |
| Halcinonide
Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent. |
| SANT-1
SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. |
Products are for research use only. Not for human use. We do not sell to patients.
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