All AbMole products are for research use only, cannot be used for human consumption.
BMS-833923 is an orally bioavailable Smoothened antagonist.
| Molecular Weight | 473.57 |
| Formula | C30H27N5O |
| CAS Number | 1059734-66-5 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Jean Y Tang, et al. Emerging treatments and signaling pathway inhibitors
| Related Smo Products |
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GDC-0449 (Vismodegib) is a potent and specific hedgehog pathway inhibitor with IC50 values of 1.4 and 3.0μM for inhibition of ABCG2 and Pgp respectively. |
| Purmorphamine
Purmorphamine is a small molecule Hh agonist which activates the hedgehog pathway by directly binding to SMO. |
| Halcinonide
Halcinonide is a high potency corticosteroid used in topical preparations as an anti-inflammatory agent. |
| SANT-1
SANT-1 directly binds to Smoothened (Smo) receptor with Kd of 1.2 nM and inhibits Smo agonist effects with IC50 of 20 nM. |
| Saikosaponin-B1
Saikosaponin B1 is a bioactive ingredient of Bupleurum chinense with anticancer activity. Saikosaponin B1 significantly inhibits tumor growth in medulloblastoma (MB) models by targeting SMO to inhibit Hedgehog pathway. |
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