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Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is widely used for neuropathic pain management in vivo.
| Molecular Weight | 310.86 |
| Formula | C17H27ClN2O |
| CAS Number | 98717-15-8 |
| Solubility (25°C) | DMSO 10 mg/mL Water 10 mg/mL |
| Storage | 2-8°C, dry, sealed |
| Related Animal experimental anesthetics Products |
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| Articaine hydrochloride
Articaine hydrochloride is a dental local anesthetic which contains an additional ester group that is metabolized by estearases in blood and tissue. Articaine hydrochloride ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway. |
| Benzocaine
Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA), it is a local anesthetic commonly used for the research of topical pain reliever or in cough drops. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV. |
| Butacaine
Butacaine is a reversible nerve conduction blocker. Butacaine acts on the nervous system and nerve fibers, can cause both sensory and motor paralysis. Butacaine inhibits mouse heart MAO (type B) and rat heart MAO (type A) with IC50 of 62 μM and 400 μM, respectively. |
| Dibucaine hydrochloride
Dibucaine (Cinchocaine) hydrochloride is a sodium channel inhibitor. Dibucaine hydrochloride is a potent SChE inhibitor. Dibucaine hydrochloride is a local anesthetics. |
| Levobupivacaine hydrochloride
Levobupivacaine hydrochloride is a long-acting amide local anaesthetic. Levobupivacaine hydrochloride exerts anaesthetic and analgesic effects through reversible blockade of neuronal sodium channel. |
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