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Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo.
Robotnikinin (50 µM) prevents the ShhN-induced LC3-II increase. Robotnikinin (5 μM) downregulates classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells, suggesting a link between Hh signaling and the NF-κB pathway in MM.
| Molecular Weight | 454.95 |
| Formula | C25H27ClN2O4 |
| CAS Number | 1132653-79-2 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage | 4°C, protect from light, sealed |
| Related Hedgehog Products |
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| Cyclopamine
Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. |
| LY2940680
LY2940680 is a potent Hedgehog inhibitor with potential anticancer activity. |
| LDE225
LDE225 (NVP-LDE225; Sonidegib) is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. |
| PF-5274857
PF-5274857 is a novel Smoothened antagonist, inhibits Hedgehog signaling with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively. |
| Jervine
Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. |
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