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Jervine inhibits the sonic hedgehog (shh) pathway by interacting with smoothened. Jervine can be used to induce abnormal morphogenesis in a number of experimental models.
| Molecular Weight | 425.6 |
| Formula | C27H39NO3 |
| CAS Number | 469-59-0 |
| Solubility (25°C) | DMSO 5mg/ml Ethanol 10mg/ml |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Blane P Zavesky, et al. Progress toward a Convergent, Asymmetric Synthesis of Jervine
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| LDE225
LDE225 (NVP-LDE225; Sonidegib) is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. |
| PF-5274857
PF-5274857 is a novel Smoothened antagonist, inhibits Hedgehog signaling with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively. |
| Ciliobrevin A
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