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Budesonide can attenuate lung injuries induced by chlorine gas, surfactant-depletion, aspiration or LPS in short-term experiments. However, long-term outcome of budesonide applications in endotoxin-induced lung injuries remains unclear. Indeed, long-term application of glucocorticoids to treat ARDS remains controversial.
| Cell Experiment | |
|---|---|
| Cell lines | NSCLC cell lines |
| Preparation method | Antagonists were added 1 h before agonists for the corresponding receptors. Charcoal stripped serum was used in the medium when cells were treated with budesonide. |
| Concentrations | 50 nM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | male New Zealand white rabbits |
| Formulation | saline |
| Dosages | 0.5 mg/kg |
| Administration | i.v. |
| Molecular Weight | 430.53 |
| Formula | C25H34O6 |
| CAS Number | 51372-29-3 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related GCR Products |
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| Dexamethasone
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist that induces the production of phospholipase A2 inhibitory protein.It can be used to construct models of allergic conjunctivitis. |
| Budesonide
Budesonide is a synthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. |
| AZD5423
AZD5423 is a novel nonsteroidal glucocorticoid receptor agonist. |
| Mometasone furoate
Mometasone furoate is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways. |
| Hydrocortisone
Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. |
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