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Protamine sulfate is a positive ionic peptide with anti-heparin activity. Protamine sulfate has strong alkaline groups, which combine with strongly acidic heparin in the body to form a stable compound, making heparin lose its anticoagulant ability.
| Formula | H2O4S |
| CAS Number | 9009-65-8 |
| Solubility (25°C) | Water ≥ 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Vance G Nielsen, et al. Anesth Analg. Protamine sulfate: crouching clot or hidden hemorrhage?
[4] No authors listed. J Am Med Assoc. PROTAMINE sulfate
[5] R Porsche, et al. Heart Lung. Allergy to protamine sulfate
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BIBR 953 (Dabigatran, Pradaxa) is an oral anticoagulant from the class of the direct thrombin inhibitors. |
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| Eltrombopag
Eltrombopag is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR). |
| Dabigatran Etexilate
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| Argatroban Monohydrate
Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. |
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