All AbMole products are for research use only, cannot be used for human consumption.
Eltrombopag (SB-497115) is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead to thrombocytopenia. In preclinical studies, the compound was shown to interact selectively with the thrombopoeitin receptor, leading to activation of the JAK-STAT signaling pathway and increased proliferation and differentiation of megakaryocytes. Animal studies confirmed that administration could increase platelet counts. In addition, eltrombopag (SB-497115) decreased proliferation of all cancer cell lines.
| Molecular Weight | 442.47 |
| Formula | C25H22N4O4 |
| CAS Number | 496775-61-2 |
| Solubility (25°C) | DMSO 27 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Phillip Scheinberg. Activity of eltrombopag in severe aplastic anemia
[3] Taylor Olmsted Kim, et al. Eltrombopag for use in children with immune thrombocytopenia
[5] Danielle M Townsley, et al. Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia
| Related Thrombopoietin/Thrombin Products |
|---|
| BIBR 953
BIBR 953 (Dabigatran, Pradaxa) is an oral anticoagulant from the class of the direct thrombin inhibitors. |
| Enoxaparine
Enoxaparine is a low molecular heparin that binds to antithrombin (AT) and accelerates its inhibition of factor Xa.Enoxaparine has a higher affinity for factor Xa than for thrombin, and its action on thrombin does not require HCII (heparin cofactor II). |
| Dabigatran Etexilate
Dabigatran Etexilate is the procompound of dabigatran, a potent, nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule. |
| Argatroban Monohydrate
Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. |
| Dabigatran etexilate mesylate
Dabigatran etexilate mesylate is a direct thrombin inhibitor. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
