All AbMole products are for research use only, cannot be used for human consumption.
PCL-PVAc-PEG is an amphiphilic polymer that enhances the solubility and bioavailability of difficult-to-solve substances and can be used in studies related to drug delivery.
The following is the information about dissolving PCL-PVAc-PEG (same as soluplus):
### Recommended Solvents
- **Water**: PCL-PVAc-PEG has good solubility in water.
- **Organic Solvents**:
- Acetone: Maximum solubility up to 50%.
- Methanol: Maximum solubility up to 45%.
- Ethanol: Maximum solubility up to 25%.
- Dimethylformamide (DMF): Maximum solubility up to 50%.
- Ethanol/Acetone (1:1 mass ratio): Maximum solubility up to 45%.
- Methanol/Acetone (1:1 mass ratio): Maximum solubility up to 50%.
### Concentration Ranges
- PCL-PVAc-PEG has high solubility in water, but high concentrations may lead to turbid or colloidal solutions.
- In organic solvents, concentrations typically range from 10% to 50% (w/w), depending on the solvent and application.
### Dissolution Conditions
- **Temperature**: PCL-PVAc-PEG may become turbid at higher temperatures (around 40°C) due to micelle formation (lower critical solution temperature, LCST), but it will return to clarity upon cooling.
- **Stirring**: Gentle stirring is recommended to accelerate dissolution.
- **Mixed Solvents**: Using mixed solvents (e.g., ethanol/acetone or methanol/acetone) can improve dissolution efficiency.
### Optimization Recommendations
1. **Select Suitable Solvents**: Choose appropriate solvents based on the specific application, such as water or organic solvents.
2. **Control Concentration**: Avoid excessively high concentrations to prevent turbidity or colloidal formation.
3. **Temperature Control**: Avoid exceeding the critical dissolution temperature (around 40°C).
4. **Mixing Method**: Use gentle stirring to ensure uniform dissolution.
These recommendations can help optimize the dissolution process of PCL-PVAc-PEG for your experimental needs.
Cell Biol Toxicol. 2025 Aug 01;41(1):122.
CD44-targeted therapy using mP6/Rg3 micelles inhibits oral cancer stem cell proliferation and migration
PCL-PVAc-PEG purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | CB CD34+ cells |
| Preparation method | A total of 2 × 10^4 human CB CD34+ cells were cultured for 14 days using 2a medium: IMDM , 1% ITSX, 1% P/S/G, 1 µmol/L 740Y-P, 0.1 µmol/L butyzamide and 0.1% PCL-PVAc-PEG and one of the following small molecules: 35–280 nmol/L UM171, 0.25–2.0 μmol/L UM729, 5–40 μmol/L tranylcypromine, 0.25–2.0 mol/L valproic acid; 1–10 μmol/L anagrelide (ANA) hydrochloride at 37°C with 5% CO2. All cultures were performed using CellBIND 24-well flat-bottomed multiwell plates. Exp Hematol. 2024 Mar;131:104138. |
| Concentrations | 0.1% PCL-PVAc-PEG |
| Incubation time | 14 days |
| Animal Experiment | |
|---|---|
| Animal models | Male Sprague-Dawley rats |
| Formulation | 0.5% carboxymethylcellulose sodium (CMC-Na) |
| Dosages | Not Mentioned |
| Administration | Oral injection |
| Molecular Weight | 591.55 |
| Formula | (C8H13NO·C4H6O2·C2H4O)x |
| CAS Number | 402932-23-4 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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|---|
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| Methyl α-D-glucopyranoside
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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