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Omaveloxolone (RTA 408) is a first-in-class antioxidant inflammatory modulator (AIM) that activates Nrf2 and inhibits nitric oxide (NO). Omaveloxolone inhibits osteoclastogenesis by inhibiting the STING-dependent NF-κb signaling pathway.
Omaveloxolone (RTA-408) is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2). Omaveloxolone (RTA-408) potently increases expression of Nrf2 target genes and reverses IFNγ-mediated suppression of Gclc expression in RAW 264.7 cells. In a panel of eight human tumor cell lines, Omaveloxolone inhibits growth with an average GI50 value of 260 nM and induces apoptosis.
J Cancer Res Clin Oncol. 2023 Apr 29.
Apatinib combined with olaparib induces ferroptosis via a p53-dependent manner in ovarian cancer
Omaveloxolone purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | U-87 MG glioblastoma cell line |
| Preparation method | Cells were then treated with omaveloxolone at concentrations of 0, 600, 800 or 1000 nM, or with vehicle (DMSO) for another 24 h. Cell viability was determined according to the manufacturer's instructions. Each treatment was performed in triplicate. The IC50 values were calculated based on cell viability measurements. |
| Concentrations | 0, 600, 800 or 1000 nM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Male nude mice |
| Formulation | 0.1% DMSO |
| Dosages | 15, 20 and 25 mg/kg |
| Administration | Intraperitoneally injected |
| Molecular Weight | 554.71 |
| Formula | C33H44F2N2O3 |
| CAS Number | 1474034-05-3 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Keap1-Nrf2 Products |
|---|
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Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. Sulforaphane promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. Sulforaphane (SFN) extracted from broccoli sprout is an agent with potent anti-oxidant and anti-inflammatory activity. |
| Ginsenoside-Rh3
Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 induces Nrf2 activation in human retinal cells. |
| Astilbin
Astilbin is a flavonoid that enhances NRF2 activation. Astilbin also inhibited TNF-α expression and NF-κB activation. |
| Luteolin
Luteolin (Luteolol) is a natural flavonoid that is a modulator of Nrf2. Luteolin exhibits dual regulation of Nrf2. In tumour cells, low concentrations of Luteolin activate the Nrf2 signalling pathway and promote Nrf2 nuclear translocation, while high concentrations of Luteolin inhibit Nrf2 activity and negatively modulate the Nrf2/ARE signalling pathway. Luteolin is also a PDE inhibitor. In addition, Luteolin has a variety of biological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotection. Luteolin can be used in studies related to ferroptosis. |
| ML 334
ML334 (LH601A) is a inhibitor of Keap1- Nrf2 interaction. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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