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Luteolin (Luteolol) is a natural flavonoid that is a modulator of Nrf2. Luteolin exhibits dual regulation of Nrf2. In tumour cells, low concentrations of Luteolin activate the Nrf2 signalling pathway and promote Nrf2 nuclear translocation, while high concentrations of Luteolin inhibit Nrf2 activity and negatively modulate the Nrf2/ARE signalling pathway. Luteolin is also a PDE inhibitor.
Luteolin (0-160 µM; 24 hours; NCI-H460 cells) treatment inhibits the viability of NCI-H460 cells in a concentration-dependent manner.
In vivo, Luteolin (10-100 mg/kg; oral gavage; daily; for 12 weeks; adult male Wistar rats) has an antioxidant effect and can also protect against non-alcoholic steatohepatitis through targeting the pro-inflammatory IL-1 and Il-18 pathways in rats with a high carbohydrate/high fat diet.
| Molecular Weight | 286.24 |
| Formula | C15H10O6 |
| CAS Number | 491-70-3 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Fabian Gendrisch, et al. Luteolin as a modulator of skin aging and inflammation
[3] Muhammad Imran, et al. Luteolin, a flavonoid, as an anticancer agent: A review
[6] Yong Lin, et al. Luteolin, a flavonoid with potential for cancer prevention and therapy
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