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Nimotuzumab (Nimotuzumab) is the first humanized monoclonal antibody targeting epidermal growth factor receptor (EGFR). Nimotuzumab has cytolytic effects on target tumors through its ability to induce antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC). EGFR is overexpressed in a variety of solid tumors, such as head and neck cancer, lung cancer and colorectal cancer. EGFR overexpression is highly associated with high aggressiveness, high metastasis, and poor prognosis. Nimotuzumab can competitively bind EGFR and block downstream signal transduction pathway mediated by EGFR, thereby inhibiting tumor cell proliferation, inducing differentiation, promoting apoptosis and inhibiting tumor angiogenesis. Nimotuzumab failed to recognize mouse EGFR.
Another CAS# 780758-10-3
| Molecular Weight | 147656.97 |
| Formula | C6566H10082N1746O2056S40 |
| CAS Number | 828933-51-3 |
| Storage | -80°C for long term |
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