All AbMole products are for research use only, cannot be used for human consumption.
Nigericin sodium salt is a potassium ionophore, exchanges K+ for H+ across biological membranes, in a similar manner to Valinomycin. Stimulates mitochondral ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius. Nigericin sodium salt is also an NLRP3 activator which can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.
Sci Rep. 2024 Sep 13;14(1):21410.
ROS exhaustion reverses the effects of hyperbaric oxygen on hemorrhagic transformation through reactivating microglia in post-stroke hyperglycemic mice
Nigericin sodium salt purchased from AbMole
Sci Rep. 2024 Sep 13;14(1):21410.
ROS exhaustion reverses the effects of hyperbaric oxygen on hemorrhagic transformation through reactivating microglia in post-stroke hyperglycemic mice
Nigericin sodium salt purchased from AbMole
Parasit Vectors. 2024 Nov 29;17(1):495.
The microneme protein1 (MIC1) of Chinese 1 Toxoplasma regulates pyroptosis through the TLR4/NLRP3 pathway in macrophages
Nigericin sodium salt purchased from AbMole
Brain Research. 2024 Jan.
Black phosphorus nanosheets inhibit glioblastoma cell migration and invasion through modulation of WNT/β-catenin and NOTCH signaling pathways
Nigericin sodium salt purchased from AbMole
Brain Res. 2023 Dec;14:1825:148710.
Electroacupuncture stimulation ameliorates cognitive impairment induced by long-term high-fat diet by regulating microglial BDNF
Nigericin sodium salt purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | MN9D, N18TG, HEK293 and MEF cells |
| Preparation method | Cells were exposed to predetermined concentrations of nigericin for the indicated time periods. |
| Concentrations | 0.1, 0.5, 1, or 2.5 μm nigericin for MN9D, N18TG, HEK293, or MEF cells, respectively. |
| Incubation time | 18 and 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Four-week-old male BALB/c mice |
| Formulation | Not mentioned |
| Dosages | 10 and 20 mg/kg |
| Administration | Intratracheal administration |
| Molecular Weight | 746.94 |
| Formula | C40H67NaO11 |
| CAS Number | 28643-80-3 |
| Solubility (25°C) | Ethanol ≥ 30 mg/mL |
| Storage | 2-8°C, dry, protect from light, sealed |
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| Doxapram hydrochloride hydrate
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| Gliquidone
Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| Pinacidil monohydrate
Pinacidil monohydrate is known to augment a time-independent outward current in cardiac tissues by activating the ATP-regulated potassium channels. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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