All AbMole products are for research use only, cannot be used for human consumption.
ML133 hydrochloride is a potent K(ir)2.1 inhibitor, which inhibits K(ir)2.1 with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5 but exhibits little selectivity against other members of Kir2.x family channels. ML133 hydrochloride has no effect on K(ir)1.1 (IC50 > 300 μM) and displays weak activity for K(ir)4.1 (76 μM) and K(ir)7.1 (33 μM). ML133 HCl also displays modest selectivity versus hERG and possesses fair ancillary pharmacology against a larger panel of GPCRs, ion channels and transporters.
Journal of Oral Science Research. 2025 May 24;(5): 413-419.
Effect of Membrane Potential on Osteogenic Differentiation of Human Dental Follicle Stem Cells and Its Electrophysiological Mechanisms
ML133 hydrochloride purchased from AbMole
Hua Xi Kou Qiang Yi Xue Za Zhi. 2022 Apr;40(2): 139–147.
Effect of inward rectifier potassium 2.1 channel on the osteogenic differentiation of human dental follicle cells and its mechanism
ML133 hydrochloride purchased from AbMole
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Source | Front Cell Neurosci (2015). Figure 3.ML133 |
| Method | CyQUANT proliferation assay | |
| Cell Lines | Microglial cells | |
| Concentrations | 20 μM | |
| Incubation Time | 24 h | |
| Results | Because both Kir2.1 blockers (Ba2+, ML133) greatly reduced migration, we asked whether their morphology changed to that of LPS-stimulated cells. It did not; and blocking Kir2.1 did not obviously affect their unipolar morphology under any of the activation states examined |
| Molecular Weight | 313.82 |
| Formula | C19H19NO.HCl |
| CAS Number | 1222781-70-5 |
| Solubility (25°C) | DMSO 48 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Potassium Channel Products |
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4-Hydroxytolbutamide |
| TAK-438
TAK-438 is a novel and potent potassium-competitive acid blocker (P-CAB) with IC50 of 19 nM. |
| Doxapram hydrochloride hydrate
Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
| Gliquidone
Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| Pinacidil monohydrate
Pinacidil monohydrate is known to augment a time-independent outward current in cardiac tissues by activating the ATP-regulated potassium channels. |
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Products are for research use only. Not for human use. We do not sell to patients.
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