All AbMole products are for research use only, cannot be used for human consumption.
Nattokinase is an enzyme extracted and purified from a Japanese food called nattō. Nattokinase is a serine protease of the subtilisin family. It exhibits a strong fibrinolytic activity. A 2009 study showed that nattokinase may be effective in catabolism of toxic amyloid fibrils associated with Alzheimer's Disease, as well as the insulin fibrils associated with diabetes and the prion peptide fibrils associated with prion diseases.
Frontiers in Plant Science. 2025 Sep 10; .
Transient expression of fulllength and mature nattokinase in Nicotiana benthamiana reveals early necrosis from full-length form and functional activity of the mature enzyme
Nattokinase purchased from AbMole
Transbound Emerg Dis. 2025 Mar 03; .
Abnormal Expression of Proteolytic Stress-Related Proteins and Protective Effect of Fibrinolytic Enzymes in Prion Diseases
Nattokinase purchased from AbMole
J Diabetes. 2023 Jul 4.
Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy
Nattokinase purchased from AbMole
Invest Ophthalmol Vis Sci. 2021 May 3;62(6):25.
Nattokinase Attenuates Retinal Neovascularization Via Modulation of Nrf2/HO-1 and Glial Activation
Nattokinase purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | 2.5% (w/v) brain homogenate |
| Preparation method | Then, proteinase K-treated samples were boiled at 95°C for 5 min and treated with nattokinase (Abmole, Houston, USA) and lumbrokinase for 5 h to evaluate the PrPSc degradation ability of these enzymes. |
| Concentrations | Not mentioned |
| Incubation time | 5 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6J mice |
| Formulation | 1 µM dissolved in 10% [v/v] DMSO in PBS |
| Dosages | 5 µM |
| Administration | Intravenous injection |
| Molecular Weight | 463.5 |
| Formula | C23H28ClN3O5 |
| CAS Number | 133876-92-3 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Enzymes & Coenzymes Products |
|---|
| Proteinase K
Proteinase K is used for digesting various proteins and common molecular biology, cell biology and other related experiments, such as genomic DNA extraction, enzyme digestion and removal. |
| Papain
Papain is a cysteine protease of the peptidase C1 family. |
| NADH disodium salt
NADH disodium salt is a coenzyme of a large number of oxidoreductases. NADH disodium salt is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, beta-oxidation and the citric acid cycle. |
| Lipoamide
Lipoamide is a coenzyme, which transfer acetyl and hydrogen in Pyruvate deacylation oxidation Process, used for pharmaceuticals. |
| NAD+
NAD+, nicotinamide adenine dinucleotide, is a coenzyme that transfers hydrogen ions and is formed by the coupling of ribosylnicotinamide 5'-diphosphate to adenosine 5'-phosphate via pyrophosphate bonding. NAD+ is the oxidized form of NADH. NAD+ is a coenzyme that is formed by the coupling of ribosylnicotinamide 5'-diphosphate to adenosine 5 '-phosphate coupled by pyrophosphate bonding. |
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Products are for research use only. Not for human use. We do not sell to patients.
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