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Miriplatin is a DNA synthesis inhibitor.
In vitro: Miriplatin suspended in LPD (miriplatin/LPD, 100 μg/mL) inhibits the growth of AH109A cells, forms platinum-DNA adducts, and induces apoptosis.
In vivo: Miriplatin (0.02-0.4 mg/20 μL) in lipiodol reduces tumor growth rates in a dose dependent manner in rats bearing AH109A tumor cells. Miriplatin/LPD (400 μg/head) significantly reduces the growth of tumor in rats bearing AH109A cells.
| Molecular Weight | 763.99 |
| Formula | C34H68N2O4Pt |
| CAS Number | 141977-79-9 |
| Form | Solid |
| Solubility (25°C) | chloroform 30 mg/mL (DMSO can inactivate Miriplatin's activity) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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