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Apaziquone is a bioreductive prodrug and a chemical analog of the older chemotherapeutic agent mitomycin C with potential antineoplastic and radiosensitization activities. In hypoxic cells, apaziquone is converted to active metabolites by intracellular reductases. Intravesical administration of 4 mg/40 ml apaziquone was well tolerated and had ablative activity against superficial bladder cancer marker lesions.
| Molecular Weight | 288.3 |
| Formula | C15H16N2O4 |
| CAS Number | 114560-48-4 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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