All AbMole products are for research use only, cannot be used for human consumption.
Methylthiouracil is an anti-thyroid agent. Methylthiouracil inhibits TNF-α and IL-6 production and NF-κB and ERK1/2 activation.
| Molecular Weight | 142.18 |
| Formula | C5H6N2OS |
| CAS Number | 56-04-2 |
| Solubility (25°C) | DMSO 24 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] J THYSSEN. Methylthiouracil therapy in thyrotoxicosis; preliminary report
[3] H W SPIER. Methylthiouracil dermatitis
[4] G D GALANTE, et al. Methylthiouracil in cardiology
[5] E D BARTELS, et al. Further observations on methylthiouracil treatment of thyrotoxicosis
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QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. |
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Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities. |
| Cepharanthine
Cepharanthine is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production. |
| JSH-23
Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. |
| Bruceine A
Brucaine A (Brucea javanica A) is a natural bitter bitter compound, extracted from the dried fruit of Brucea javanica, which can act on dog scorch. |
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