All AbMole products are for research use only, cannot be used for human consumption.
Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM.
FASEB J. 2025 Jan 31;39(2):e70354.
In vitro stretch modulates mitochondrial dynamics and energy metabolism to induce smooth muscle differentiation in mesenchymal stem cells
Mdivi-1 purchased from AbMole
Phytomedicine. 2024 Sep 22.
Melatonin protects RPE cells from necroptosis and NLRP3 activation via promoting SERCA2-related intracellular Ca2+ homeostasis
Mdivi-1 purchased from AbMole
Poult Sci. 2024 Oct 24.
Selenomethionine alleviates kidney necroptosis and inflammation by restoring lipopolysaccharide-mediated mitochondrial dynamics imbalance via the TLR4/RIPK3/DRP1 signaling pathway in laying hens
Mdivi-1 purchased from AbMole
J Transl Med. 2023 Jan 13;21(1):24.
Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy
Mdivi-1 purchased from AbMole
J Transl Med. 2023 Jan 13;21(1):24.
Alamandine/MrgD axis prevents TGF-β1-mediated fbroblast activation via regulation of aerobic glycolysis and mitophagy
Mdivi-1 purchased from AbMole
J Agric Food Chem. 2023 Oct 4;71(39):14276-14288.
Folic Acid Protects against Ethanol-Induced Hepatic Mitophagy Imbalance by ROS Scavenging and Attenuating the Elevated Hcy Levels
Mdivi-1 purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | RPE cells |
| Preparation method | RPE cells were treated with 2.5 μM Mdivi-1 (Abmole Bioscience, M2830) for 24 h before SI treatment and Mitochondrial Ca2+ was measured by Rhod2-AM staining. |
| Concentrations | 2.5 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6 mice, 3 months of age |
| Formulation | DMSO |
| Dosages | 50 mg/kg |
| Administration | mdivi-1 (50 mg/kg in DMSO, IP injection; n = 30 mice/group) given 60 minutes before and 6 hours after ischemia |
| Molecular Weight | 353.22 |
| Formula | C15H10Cl2N2O2S |
| CAS Number | 338967-87-6 |
| Solubility (25°C) | DMSO 75 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Lin Li, et al. Mdivi-1 alleviates atopic dermatitis through the inhibition of NLRP3 inflammasome
[3] Barbara Koch, et al. Mdivi-1 and mitochondrial fission: recent insights from fungal pathogens
[4] George Smith, et al. To mdivi-1 or not to mdivi-1: Is that the question?
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|---|
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TAT-P110, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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