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Inosine

Cat. No. M10132

All AbMole products are for research use only, cannot be used for human consumption.

Inosine Structure
Synonym:

Atorel; HXR; Hypoxanthine D-riboside

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 30  USD30 In stock
500mg USD 25  USD25 In stock
1g USD 30  USD30 In stock
5g USD 45  USD45 In stock
10g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Inosine is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose, with immunomodulatory, neuroprotective, and analgesic properties. Inosine stimulates axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models. Inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway.

Product Citations
Chemical Information
Molecular Weight 268.23
Formula C10H12N4O5
CAS Number 58-63-9
Solubility (25°C) Water 20 mg/mL
DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yuhan Zhang, et al. Molecules. Inosine and D-Mannose Secreted by Drug-Resistant Klebsiella pneumoniae Affect Viability of Lung Epithelial Cells

[2] Stella Celio Junqueira, et al. Mol Neurobiol. Inosine, an Endogenous Purine Nucleoside, Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis: a Role for A2A Adenosine Receptor

[3] J W Phillis, et al. J Cereb Blood Flow Metab. Increases in cerebral cortical perfusate adenosine and inosine concentrations during hypoxia and ischemia

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Keywords: Inosine, Atorel; HXR; Hypoxanthine D-riboside supplier, Adenosine Receptor, inhibitors, activators

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