All AbMole products are for research use only, cannot be used for human consumption.
GW-870086 is a glucocorticoid receptor agonist, with pIC50 of 10.1 in A549 cells expressing NF-κB. GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC50s, 9.6, 10.2). GW-870086 (10-100 nM) significantly increases fibronectin secretion.
| Molecular Weight | 559.64 |
| Formula | C31H39F2NO6 |
| CAS Number | 827319-43-7 |
| Solubility (25°C) | DMSO ≥ 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related GCR Products |
|---|
| Dexamethasone
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist that induces the production of phospholipase A2 inhibitory protein.It can be used to construct models of allergic conjunctivitis. |
| Budesonide
Budesonide is a synthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. |
| AZD5423
AZD5423 is a novel nonsteroidal glucocorticoid receptor agonist. |
| Mometasone furoate
Mometasone furoate is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways. |
| Hydrocortisone
Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
