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FTI-2153

Cat. No. M21382

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FTI-2153 Structure

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Quality Control & Documentation
Biological Activity

FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase) with an IC50 of 1.4 nM. FTI-2153 effectively inhibits the processing modification of H-Ras protein with an IC50 value of 10 nM, and its inhibitory activity is more than 3000 times that of the processing of Rap1A protein.

Chemical Information
Molecular Weight 466.6
Formula C25H30N4O3S
CAS Number 344900-92-1
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Maria E Balasis, et al. Clin Cancer Res. Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice

[2] Niranjan Yanamandra, et al. J Pharmacol Exp Ther. Tipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells depends on Ca2+ influx through plasma membrane Ca2+ channels

[3] Bruno B Bordier, et al. J Clin Invest. In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus

[4] N C Crespo, et al. Cell Death Differ. The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status

[5] N C Crespo, et al. J Biol Chem. The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells

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Keywords: FTI-2153 supplier, Farnesyl Transferase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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