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Fti-277 Hydrochloride, an FTase inhibitor of Farnici transferase, is a highly effective Ras CAAX peptide analog that inhibits H-RAS and K-RAS signal transduction. Fti-277 hydrochloride inhibits hepatitis delta virus (HDV) infection.
| Molecular Weight | 484.075 |
| Formula | C22H30ClN3O3S2 |
| CAS Number | 180977-34-8 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | 4°C, dry, sealed |
| Related Farnesyl Transferase Products |
|---|
| Tipifarnib
Tipifarnib (IND 58359) inhibited Farnesitransferase (FTase) with an IC50 of 0.86 nM. Tipifarnib has potential antitumor activity. Tipifarnib can inhibit exosome release of tumor cells. |
| LB42708
LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively. |
| Tipifarnib S enantiomer
Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib, Tipifarnib S enantiomer is the less active isomer. |
| L-778123 hydrochloride
L-778123 hydrochloride is a dual inhibitor of FPTase and GGptase-I with IC50 values of 2 nM and 98 nM, respectively. |
| Manumycin A
Manumycin A is a selective, competitive inhibitor of protein farnesyl transferase (FTase) with respect to farnesylpyrophosphate (Ki=1.2 μM), and as a noncompetitive inhibitor with respect to the Ras protein. Manumycin A is also an antibiotic. |
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