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Denifanstat (TVB-2640) is an orally potent selective FASN inhibitor.IC50 to 0.052 μM,EC50 is 0.072 μM. Denifanstat has the potential to be used in fatty liver and cancer research.
J Virol. 2025 Feb 05.
The Japanese encephalitis virus NS1 protein concentrates ER membranes in a cytoskeleton-independent manner to facilitate viral replication
Denifanstat purchased from AbMole
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| Animal models | female C57/BL6 mice |
| Formulation | formulated in 10% DMSO, 40% PEG300, 5% Tween-80, 45% saline |
| Dosages | 25 mg/kg |
| Administration | daily gavage |
| Molecular Weight | 439.55 |
| Formula | C27H29N5O |
| CAS Number | 1399177-37-7 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 4°C, protect from light |
| Related FAS Products |
|---|
| C75
C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS). C75 inhibits prostate cancer cells PC3 with an IC50 of 35 μM. C75 is a potent CPT1A activator. |
| Orlistat
Orlistat is an irreversible inhibitor of pancreatic and gastric lipases with IC50 of 122 ng/ml for PL from human duodenal juice. |
| Betulin
Betulin is a specific, small molecule inhibitor of SREBP (Sterol Regulatory Element-Binding Proteins). |
| Pseudoprotodioscin
Pseudoprotodioscin, a furan glucoside, inhibits sREBP1/2 and microRNA 33A/B levels and reduces the expression of genes associated with cholesterol and triglyceride synthesis. |
| Albaspidin-AP
Albaspidin AP inhibited fatty acid synthase (FAS) with IC50 value of 71.7 μM. Fatty acid synthase is emerging as a potential therapeutic target for cancer and obesity. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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