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Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN). Orlistat is a compound that promotes loss of weight by preventing the digestion and absorption of fat in food. It is intended for use in conjunction with a physician-supervised reduced-calorie diet. Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. In vitro experiments demonstrate that orlistat has an IC50 of 122 ng/ml for PL from human duodenal juice, but an IC50 of about 300 ng/ml for LPL.
| Molecular Weight | 495.73 |
| Formula | C29H53NO5 |
| CAS Number | 96829-58-2 |
| Solubility (25°C) | DMSO 89 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related FAS Products |
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| C75
C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS). C75 inhibits prostate cancer cells PC3 with an IC50 of 35 μM. C75 is a potent CPT1A activator. |
| Betulin
Betulin is a specific, small molecule inhibitor of SREBP (Sterol Regulatory Element-Binding Proteins). |
| Pseudoprotodioscin
Pseudoprotodioscin, a furan glucoside, inhibits sREBP1/2 and microRNA 33A/B levels and reduces the expression of genes associated with cholesterol and triglyceride synthesis. |
| Albaspidin-AP
Albaspidin AP inhibited fatty acid synthase (FAS) with IC50 value of 71.7 μM. Fatty acid synthase is emerging as a potential therapeutic target for cancer and obesity. |
| Pedunculoside
Pedunculoside plays a lipid-lowering role by regulating lipid formation and fatty acid β -oxidation. |
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Products are for research use only. Not for human use. We do not sell to patients.
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