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The results of the current study demonstrate that the HRPE cells express the reduced-folate transporter that mediates the cellular uptake of N5 methyltetrahydrofolate, the predominant form of folate in blood.
| Cell Experiment | |
|---|---|
| Cell lines | HRPE cells |
| Preparation method | One milliliter of a hypotonic medium (10 mM Tris-HCl buffer, pH 8) containing 1 μM unlabeled N5-methyltetrahydrofolate was added to each well, and die cells were lysed by freezing and thawing. |
| Concentrations | 1 μM |
| Incubation time | 2 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 497.52 |
| Formula | C20H23CaN7O6 |
| CAS Number | 26560-38-3 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Antifolate Products |
|---|
| Pemetrexed disodium
Pemetrexed is a novel antifolic acid antimetabolic compound with K I of 1.3 nM, 7.2 nM, and 65 nM for TS, DHFR, and GARFT, respectively. |
| Methotrexate
Methotrexate (Amethopterin) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. |
| Folinic acid calcium salt
Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended |
| Sulfamethazine
Sulfamethazine is a sulfonamide antibacterial. |
| Pyrimethamine
Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM. |
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