All AbMole products are for research use only, cannot be used for human consumption.
Methotrexate (Amethopterin) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate (Amethopterin) inhibits dihydrofolate reductase (DHFR), resulting in inhibition of purine nucleotide and thymidylate synthesis. Methotrexate (Amethopterin) performed growth inhibitory activity with median IC50 78 nM in a panel of six pediatric leukemia and lymphoma cell lines.
| Molecular Weight | 454.44 |
| Formula | C20H22N8O5 |
| CAS Number | 59-05-2 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
| Related Antifolate Products |
|---|
| Pemetrexed disodium
Pemetrexed is a novel antifolic acid antimetabolic compound with K I of 1.3 nM, 7.2 nM, and 65 nM for TS, DHFR, and GARFT, respectively. |
| Folinic acid calcium salt
Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended |
| Sulfamethazine
Sulfamethazine is a sulfonamide antibacterial. |
| Pyrimethamine
Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM. |
| Methotrexate metabolite
Methotrexate metabolite is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
