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Govorestat (AT-007) is a central nervous system (CNS)-permeable aldose reductase inhibitor that prevents the conversion of glucose to sorbitol and may be used in studies related to neurological disorders.
| Molecular Weight | 425.4 |
| Formula | C17H10F3N3O3S2 |
| CAS Number | 2170729-29-8 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Aldose Reductase Products |
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| Isoliquiritigenin
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM. |
| Soyasaponin-Bb
Soyasaponin Bb is a soybean saponin isolated from the legume family that acts asa differential inhibitor of aldose reductase (ARDI). |
| Calceolarioside-B
Calceolarioside B is a natural product isolated from the Stauntonia hexaphylla leaf. Calceolarioside B showed significant inhibitory activity against aldose reductase (RLAR) in rat lens with IC50 value of 23.99 μM. Calceolarioside B could effectively inhibit DPPH radical scavenging activity with IC50 value of 94.60 μM. |
| Poliumoside
Poliumoside, a coffee-acylated phenylpropane glycoside isolated from the stems and leaves of Brandisia hancei. Poliumoside inhibited the formation of advanced glycation end products (AGE) and rat lens aldose reductase (RLAR) with IC50 values of 19.69 and 8.47 μM, respectively. Poliumoside also has anti-inflammatory and antioxidant activities. |
| Ponalrestat
Ponalrestat is an orally active, selective and noncompetitive aldose reductase inhibitor. |
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