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Ponalrestat is an orally active, selective and noncompetitive aldose reductase inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat activates lipoprotein lipase (LPL) activity in the adipose tissue and alleviates the cachectic symptoms induced by B16 melanoma in mice. Ponalrestat is effective in the attenuation of the cachectic symptoms induced by human melanomas G361 and SEKI in nude mice.
| Molecular Weight | 391.19 |
| Formula | C17H12BrFN2O3 |
| CAS Number | 72702-95-5 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Aldose Reductase Products |
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| Isoliquiritigenin
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM. |
| Soyasaponin-Bb
Soyasaponin Bb is a soybean saponin isolated from the legume family that acts asa differential inhibitor of aldose reductase (ARDI). |
| Calceolarioside-B
Calceolarioside B is a natural product isolated from the Stauntonia hexaphylla leaf. Calceolarioside B showed significant inhibitory activity against aldose reductase (RLAR) in rat lens with IC50 value of 23.99 μM. Calceolarioside B could effectively inhibit DPPH radical scavenging activity with IC50 value of 94.60 μM. |
| Poliumoside
Poliumoside, a coffee-acylated phenylpropane glycoside isolated from the stems and leaves of Brandisia hancei. Poliumoside inhibited the formation of advanced glycation end products (AGE) and rat lens aldose reductase (RLAR) with IC50 values of 19.69 and 8.47 μM, respectively. Poliumoside also has anti-inflammatory and antioxidant activities. |
| Ganoderic acid C2
Ganoderic acid C2 is a biologically active triterpenoid in Ganoderic acid C2 with potential anti-tumor biological activity, with antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 has a high inhibitory activity against rat lens aldose reductase (RLAR), which IC50 The value is 3.8 μM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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