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Angiotensin (1-7) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7), inhibits purified canine angiotensin converting enzyme (ACE) activity with an IC50 of 0.65 μM. At a concentration of 2 μM Angiotensin (1-7), relaxation to BK is increased 92% compared to BK alone (41±4.4% versus 92±2.5%, P<0.01). Angiotensin (1-7) possesses novel biological functions that are distinct from Ang II.
Clin Cosmet Investig Dermatol. 2024 May 8:.
Angiotensin (1-7) Inhibits Transforming Growth Factor-Β1-Induced Epithelial-Mesenchymal Transition of Human Keratinocyte Hacat Cells in vitro
Talfirastide purchased from AbMole
| Molecular Weight | 899.0 |
| Formula | C41H62N12O11 |
| CAS Number | 51833-78-4 |
| Solubility (25°C) | Water: ≥ 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Khajah MA, et al. PLoS One. Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis.
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