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Azilsartan (TAK-536) is an angiotensin II receptor antagonist used in the treatment of hypertension. Azilsartan potently inhibited vascular cell proliferation in the absence of exogenously supplemented angiotensin II. Azilsartan increased tissue glucose uptake, especially in skeletal muscle and adipose tissue. In cultured 3T3-L1 preadipocytes, azilsartan enhanced adipogenesis and exerted greater effects than valsartan on expression of genes encoding peroxisome proliferator-activated receptor-α (PPARα), PPARδ, leptin, adipsin, and adiponectin. In adipose tissue, Azilsartan (TAK-536) reduced TNF-alpha expression but increased the expression of adiponectin, PPARgamma, C/EBalpha, and aP2. In addition, azilsartan downregulated 11β-hydroxysteroid dehydrogenase type 1 expression. Azilsartan is currently in a phase IV clinical trial in the treatment of hypertension.
Tampere University. 2021.
Novel Targeted Therapies and Prognostic Markers for T Cell Acute Lymphoblastic Leukemia
Azilsartan purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | male Wister rats, aged 6–8 weeks |
| Formulation | Na-CMC |
| Dosages | 3.5 mg/kg, 7 mg/kg |
| Administration | p.o. |
| Molecular Weight | 456.45 |
| Formula | C25H20N4O5 |
| CAS Number | 147403-03-0 |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Angiotensin Receptor Products |
|---|
| Azilsartan medoxomil
Azilsartan Medoxomil is an effective angiotensin II Type 1 (AT1) receptor antagonist that inhibits RAAS more than 10,000 times more selectively than AT2, and is used to study hypertension. |
| PD 123319 ditrifluoroacetate
PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist. |
| Losartan potassium
Losartan potassium is a selective non-peptide angiotensin AT1 receptor antagonist. |
| Eprosartan Mesylate
Eprosartan is a nonpeptide angiotensin II receptor antagonist, [3H]-eprosartan binds to the AT1 receptor with KD of 0.83 nM in rat vascular smooth muscle cells. |
| Olmesartan
Olmesartan is an angiotensin II receptor antagonist with an IC50 of 7.7 nM. |
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